Anaplastic Large Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells. The majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein. The most frequently seen genetic alteration is a t(2;5) translocation. Majority of patients present with advanced disease. The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001)

**Synonyms:** - ALCL - ALCL - Anaplastic Large Cell Lymphoma, T Cell and Null Cell Type - Anaplastic large cell lymphoma, CD30+ - Anaplastic large cell lymphoma, NOS - CD30 Positive Anaplastic Large Cell Lymphoma - Ki-1 Lymphoma - Ki-1+ ALCL - Ki-1+ Anaplastic Large Cell Lymphoma - NHL, anaplastic large cell lymphoma - anaplastic large cell lymphoma