Dactinomycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)

**Synonyms:** - 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 - ACTINOMYCIN D - Actinomycin A IV - Actinomycin C1 - Actinomycin D - Actinomycin I1 - Actinomycin IV - Actinomycin IV - Actinomycin X 1 - Actinomycin X 1 - Actinomycin-[thr-val-pro-sar-meval] - Cosmegen - Cosmegen - DACT - DACTINOMYCIN - Dactinomycine - Lyovac Cosmegen - Lyovac cosmegen - Meractinomycin - Meractinomycin - dactinomycin