Demecolcine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A colchicine analog with potential antimitotic and antineoplastic activities. Demecolcine acid binds to the colchicine-binding site of tubulin, inhibiting its polymerization into microtubules, causing cell cycle arrest at metaphase and preventing cell division.

**Synonyms:** - (-)-Colchamine - DEMECOLCINE - DEMECOLCINE - Methylcolchicine - N-Methyl-N-desacetylcolchicine - Santavy's Substance F - X 153