NUT Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene.

**Synonyms:** - Carcinoma with t(15;19)(q13;p13.1) Translocation - Midline Carcinoma of Children and Young Adults with NUT Rearrangement - Midline carcinoma of children and young adults with NUT rearrangement - NMC - NUT Midline Carcinoma - NUT carcinoma - NUT midline carcinoma - Nuclear Protein in Testis (NUT) Midline Carcinoma - Nuclear Protein in Testis Midline Carcinoma