Anaplastic Ganglioglioma

**Semantic type:** Neoplastic Process

**Definition:** A WHO grade III neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. The anaplastic changes in the glial component and high MIB-1 and TP53 labeling indices may indicate aggressive behavior. However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO)

**Synonyms:** - Ganglioglioma, anaplastic