Norfloxacin

**Semantic type:** Antibiotic|Pharmacologic Substance

**Definition:** A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms.

**Synonyms:** - 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid - Baccidal - Fulgram - MK-366 - NORFLOXACIN - Noroxin - Sebercim