Fluoroquinolone Antibiotic

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any quinolone antibiotic with a fluorine (F) atom attached to the quinolone structure, with broad-spectrum antibacterial activity. Fluoroquinolones diffuse through the bacterial cell wall and act by inhibiting bacterial topoisomerase II, DNA gyrase and/or bacterial topoisomerase IV, which are enzymes involved in bacterial DNA replication. This prevents DNA replication and leads to a blockage of bacterial cell proliferation.

**Synonyms:** - Fluoroquinolone - Fluoroquinolones