Taxane Analogue TPI 287

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.

**Synonyms:** - TPI 287