Larotaxel

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

**Synonyms:** - LAROTAXEL - RPR 109881A - RPR 109881A - RPR-109881 - Taxoid-109881 - XRP9881