Belinostat

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.

**Synonyms:** - BELINOSTAT - Beleodaq - PXD 101 - PXD 101 - PXD-101 - PXD101 - PXD101 - belinostat