Paromomycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** An aminoglycoside antibiotic derived from Streptomyces rimosus var. paromomycinus, with amebicidal and antibacterial activity. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation, thereby leading to inhibition of protein synthesis followed by cell death.

**Synonyms:** - Antibiotic 503-3 - Antibiotic SF 767B - Estomycin - Gabromycin - Hydroxymycin - Monomycin A - Neomycin E - O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-O-Beta-D-Ribofuranosyl-(1->5)-O-(2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4))-2-Deoxystreptamine - O-2-Amino-2-Deoxy-Alpha-D-Glucopyranosyl-(1->4)-O-(O-2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl-(1->3)-Beta-D-Ribofuranosyl-(1->5))-2-Deoxy-D-Streptamine - PAROMOMYCIN - Paromomycin I - Paucimycin - Quintomycin C - R-400