Riviciclib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Riviciclib selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.

**Synonyms:** - Cyclin Dependent Kinase Inhibitor P276 - P-276-00 Free Base - P276 - P276-00 - RIVICICLIB