Mopidamol

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A derivative of dipyridamole that is a phosphodiesterase inhibitor, with potential antiplatelet activity. Mopidamol inhibits the hydrolysis of cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), by cyclic nucleotide phosphodiesterases; thus, cAMP- and cGMP-dependent processes are potentiated. This leads to the induction of prostacyclin synthesis, the inhibition of thromboxane B2 synthesis and prevention of platelet activation and aggregation.

**Synonyms:** - 2,2',2",2"'-[(4-Piperidinopyrimido[5,4-d-]pyrimidine-2,6-diyl)dinitrilo]tetraethanol - 2,2',2",2"'-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol - 2,6-Bis(diethanolamino)-4-piperidino-pyrimido[5,4-d]pyrimidine - MOPIDAMOL - RA-233 - Rapenton