Cabazitaxel

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

**Synonyms:** - 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate] - CABAZITAXEL - Jevtana - Jevtana - RPR 116258A - RPR-116258A - RPR116258A - TXD 258 - TXD-258 - TXD258 - Taxoid XRP6258 - XRP 6258 - XRP-6258 - XRP6258 - cabazitaxel - taxoid XRP6258