Daniquidone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent.

**Synonyms:** - 8-Aminoisoindolo(1,2-b)quinazolin-12(10H)-one - Batracylin - Bay H 2049 - DANIQUIDONE - batracylin