Ofloxacin

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04)

**Synonyms:** - 9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL- - DL-8280 - Floxin - HOE 280 - OFLOXACIN - Ocuflox - ofloxacin