Amonafide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.

**Synonyms:** - 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl) - AMONAFIDE - BIDA - Benzisoquinolinedione - Benzisoquinolinedione - M-FA-142 - amonafide