Pracinostat

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors.

**Synonyms:** - 2-propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1h-benzimidazol-5-yl)-N-hydroxy-, (2E)- - HDAC Inhibitor SB939 - PRACINOSTAT - SB 939 - SB-939 - SB939 - SB939 - kaempferol 3-o-beta-d-(6-E-P-coumaroylglucoside)