Olaparib

**Semantic type:** Pharmacologic Substance

**Definition:** A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

**Synonyms:** - AZD 2281 - AZD-2281 - AZD2281 - AZD2281 - KU 0059436 - KU-0059436 - KU0059436 - Lynparza - OLAPARIB - Olanib - Olaparix - PARP Inhibitor AZD2281 - PARP inhibitor AZD2281 - olaparib