Losoxantrone Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of losoxantrone, an anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.

**Synonyms:** - LOSOXANTRONE HYDROCHLORIDE - Losoxantrone HCl - Losoxantrone Hydrochloride Hydrate