ALK-Positive Large B-Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** A usually aggressive large B-cell lymphoma characterized by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack the 2;5 translocation.

**Synonyms:** - ALK positive large B-cell lymphoma - ALK-DLBCL - Diffuse Large B-Cell Lymphoma with Expression of Full-Length ALK - Diffuse Large B-Cell Lymphoma with Expression of Full-Length Anaplastic Lymphoma Kinase