PI3K Inhibitor BGT226

**Semantic type:** Pharmacologic Substance

**Definition:** A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.

**Synonyms:** - BGT226 - NVP-BGT-226 Free Base - NVP-BGT226 Free Base