Puromycin Hydrochloride

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** The hydrochloride salt form of puromycin, an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; it is used as an antibiotic in cell culture.

**Synonyms:** - PUROMYCIN HYDROCHLORIDE