Nocodazole

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.

**Synonyms:** - Methyl (5-(2-thienylcarbonyl))-1H-benzimidazol-2-yl - NOCODAZOLE