Tivirapine

**Semantic type:** Pharmacologic Substance

**Definition:** A benzodiazepine non-nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency viruses 1 and 2 and simian immunodeficiency virus. Tivirapine inhibits replication in both wild-type and drug-resistant HIV-1 isolates.

**Synonyms:** - (S)-8-Chloro-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo(4,5,1-jk)(1,4)benzodiazepine-2(1H)-thione - 8-chloro-TIBO - TIVIRAPINE