DS Stage I Multiple Myeloma

**Semantic type:** Neoplastic Process

**Definition:** Multiple myeloma with all of the following: 1. Hemoglobin greater than 10 g/Dl, 2. Normal serum calcium, 3. Normal bone structure, 4. Low monoclonal (or myeloma) protein (M protein) production as shown by: a. IgG less than 5.0 g/dL, b. IgA less than 3.0 g/dL, c. Urinary kappa or lamda less than 4 g/24 hours. Estimated myeloma cell mass: less than 0.6 trillion (1012)/m2 (low burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage I quite differently: Beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). (PDQ)

**Synonyms:** - DS Stage I Multiple Myeloma/Plasma Cell Myeloma - DS Stage I Plasma Cell Myeloma - Durie/Salmon Stage I Multiple Myeloma - Durie/Salmon Stage I Plasma Cell Myeloma - Multiple Myeloma Stage I - Stage I Multiple Myeloma - Stage I Plasma Cell Myeloma - stage I multiple myeloma