DS Stage II Multiple Myeloma

**Semantic type:** Neoplastic Process

**Definition:** Multiple myeloma that fits in neither stage I nor stage III. Estimated myeloma cell mass: 0.6 to 1.2 trillion (1012)/m2 (intermediate burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL, b. Creatinine greater than or equal to 2.0 mg/dL. Impaired renal function worsens prognosis regardless of stage. Note that the newer International Staging System defines stage II quite differently: Beta-2-microglobulin less than 3.5 and albumin less than 3.5 or beta-2-microglobulin 3.5 to less than 5.5 (median survival of 44 months). (PDQ)

**Synonyms:** - DS Stage II Multiple Myeloma/Plasma Cell Myeloma - DS Stage II Plasma Cell Myeloma - Durie/Salmon Stage II Multiple Myeloma - Durie/Salmon Stage II Plasma Cell Myeloma - Multiple Myeloma Stage II - Stage II Multiple Myeloma - Stage II Plasma Cell Myeloma - stage II multiple myeloma