Camsirubicin

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Camsirubicin intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.

**Synonyms:** - 5-Imino-13-deoxydoxoubicin - CAMSIRUBICIN - GPX-150 - GPX150