Lymphomatoid Granulomatosis

**Semantic type:** Neoplastic Process

**Definition:** An angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells. Incidence is higher among adult males; patients with a history of immunodeficiency are at increased risk. The most common site of involvement is the lung; other common sites include brain, kidney, liver, and skin. Morphologically, three grades are recognized: grade I, II, and III. Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma.

**Synonyms:** - LYG - Lymphomatoid granulomatosis - Lymphomatoid granulomatosis - lymphomatoid granulomatosis