Bizaxofusp

**Semantic type:** Pharmacologic Substance

**Definition:** A fusion protein consisting of the cytokine interleukin-4 (IL-4) linked to a truncated form of Pseudomonas exotoxin with potential antineoplastic activity. Upon specific, high-affinity binding to IL-4 receptors located on the tumor cell surface., bizaxofusp is internalized; the exotoxin moiety then binds to translation elongation factor 2 (EF-2), which may result in ADP ribosylation, deactivation of EF-2, inhibition of protein synthesis, and tumor cell apoptosis. The Pseudomonas exotoxin moiety of this agent has been engineered to reduce non-specific binding to cells expressing its receptor, the multiligand cell surface receptor alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (alpha 2MR/LRP). IL-4R is a type I transmembrane protein that binds IL-4 and IL-13 and may be overexpressed by cancers such as renal cell carcinoma and glioma.

**Synonyms:** - BIZAXOFUSP - IL-4 Fusion Toxin - IL-4 PE38KDEL Immunotoxin - IL4-PE - IL4-Pseudomonas Exotoxin Fusion Protein MDNA55 - INxin - Interleukin-4 Fusion Toxin - Interleukin-4 PE38kdel Immunotoxin - Interleukin-4 Pseudomonas Exotoxin - MDNA55 - NBI-3001 - NBI-3001 - PRX-321 - PRX321 - interleukin-4 PE38KDEL cytotoxin - interleukin-4 pe38kdel immunotoxin