B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

**Semantic type:** Neoplastic Process

**Definition:** A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome.

**Synonyms:** - B Acute Lymphoblastic Leukemia with ETV6-RUNX1 Fusion - B Acute Lymphoblastic Leukemia with ETV6::RUNX1 Fusion - B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6::RUNX1 - B Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) - B-ALL with t(12;21)(p13.2;q22.1)/ETV6-RUNX1 - B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1 - B-Acute Lymphoblastic Leukemia with ETV6-RUNX1 Fusion - B-Acute Lymphoblastic Leukemia with ETV6::RUNX1 Fusion - B-Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) - B-Cell Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)