Lurbinectedin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.

**Synonyms:** - LURBINECTEDIN - PM 01183 - PM-01183 - PM01183 - Zepzelca