Pixantrone Dimaleate

**Semantic type:** Pharmacologic Substance

**Definition:** The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.

**Synonyms:** - 6,9-Bis((2-Aminoethyl)Amino)Benzo(g)Isoquinoline-5,10-Dione (2z)-But-2-Enedioate (1:2) - BBR 2778 - BBR 2778 - BBR-2778 - BBR2778 - Benz(g)Isoquinoline-5,10-Dione, 6,9-Bis((2-Aminoethyl)Amino)-, (2z)-2-Butenedioate (1:2) - Benz(g)isoquinoline-5,10-dione, 6,9-bis((2-aminoethyl)amino)-, (2Z)-2-butenedioate (1:2) - PIXANTRONE DIMALEATE - Pixantrone Maleate - Pixuvri