Lersivirine

**Semantic type:** Pharmacologic Substance

**Definition:** A next-generation, pyrazole non-nucleoside reverse transcriptase inhibitor. Lersivirine retains activity against HIV viruses with mutations at position Y181, which confers resistance to efavirenz, etravirine, and nevirapine.

**Synonyms:** - 1,3-Benzenedicarbonitrile, 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)- - 5-((3,5-Diethyl-1-(2-Hydroxyethyl)-1H-Pyrazol-4-yl)Oxy)Benzene-1,3-Dicarbonitrile - LERSIVIRINE - UK-453,061 - UK-453061