Nemorubicin Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of nemorubicin, a morpholinyl analogue of the anthracycline doxorubicin with antineoplastic activity. Nemorubicin is metabolized via the P450 CYP3A enzyme to a highly cytotoxic derivative. Unlike most anthracyclines, nemorubicin is a topoisomerase I inhibitor and appears to exert its effect through the nucleotide excision repair (NER) system. In addition, this agent does not show cross-resistance with other anthracyclines.

**Synonyms:** - 5,12-Naphthacenedione, 7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-10-((2,3,6-Trideoxy-3-((2S)-2-Methoxy-4-Morpholinyl)-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-, Hydrochloride, (8S,10S)- - NEMORUBICIN HYDROCHLORIDE