Teniposide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)

**Synonyms:** - 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside) - 4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside - EPT - PTG - TENIPOSIDE - Thenylidene Lignan - VM 26 - VM-26 - VM-26 - VM26 - Vehem - Vehem - Vumon - Vumon - [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one - teniposide