Mivobulin

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic, colchicine analogue with potential antineoplastic activity. Mivobulin targets and binds to colchicine-binding site on tubulin, thereby inhibiting microtubule polymerization, the assembly of the mitotic spindle and mitosis. This eventually results in cell cycle arrest, apoptosis and a reduction in cellular proliferation.

**Synonyms:** - Carbamic Acid, (5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido(3,4-B)Pyrazin-7-Yl) Ethyl Ester, (S)- - Ethyl (S)-5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido(3,4-B)Pyrazine-7-Carbamate - MIVOBULIN