Crilvastatin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A pyrrolidone non-competitive inhibitor of hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase. Crilvastatin acts by stimulating LDL-cholesterol uptake by hepatocytes and also by stimulating bile cholesterol and bile salt secretion.

**Synonyms:** - 5-Oxo-L-proline, (+-)-cis-3,3,5-trimethylcyclohexyl Ester - CRILVASTATIN - PMD-387