CENP-E Inhibitor GSK-923295A

**Semantic type:** Pharmacologic Substance

**Definition:** A small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295A binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase.

**Synonyms:** - Centromere-Associated Protein E Inhibitor GSK-923295 - GSK 923295 - GSK 923295A - GSK-923295 - GSK-923295A - GSK-923295A - GSK923295 - GSK923295A