Primary Mediastinal Large B-Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** A large B-cell non-Hodgkin lymphoma arising in the mediastinum. Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis. Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001)

**Synonyms:** - B-Cell Diffuse Large Cell Lymphoma of Mediastinum - B-Cell Diffuse Large Cell Lymphoma of the Mediastinum - Mediastinal (Thymic) Large B-Cell Lymphoma - Mediastinal (Thymic) Large B-Cell Lymphoma - Mediastinal (Thymic) Large B-Cell Lymphoma - Mediastinal (thymic) large B-cell lymphoma - Mediastinal (thymic) large B-cell lymphoma - Mediastinal (thymic) large B-cell lymphoma, unspecified site - Mediastinal B-Cell Diffuse Large Cell Lymphoma - Mediastinal Diffuse Large Cell Lymphoma with Sclerosis - Mediastinal large B-cell lymphoma - PMBL - PMLCL - Primary Mediastinal (Thymic) Large B-Cell Lymphoma - Primary Mediastinal (Thymic) Large B-Cell Lymphoma - Primary Mediastinal (Thymic) Large B-Cell Lymphoma - Primary Mediastinal (Thymic) Large B-Cell Lymphoma - Primary Mediastinal Clear Cell Lymphoma of B-Cell Type - Thymic large B-cell lymphoma