Esophageal Sarcomatoid Squamous Cell Carcinoma

**Semantic type:** Neoplastic Process

**Definition:** A subtype of esophageal squamous cell carcinoma with polypoid growth characterized by a biphasic pattern of neoplastic squamous epithelial cells and spindle or pleomorphic sarcomatous cells. The squamous cell component is usually well to moderately differentiated or occasionally may be carcinoma in situ. The sarcomatous component is a high-grade malignancy that may exhibit heterologous elements.

**Synonyms:** - Esophageal Carcinoma with Mesenchymal Stroma - Esophageal Carcinosarcoma - Esophageal Metaplastic Carcinoma - Esophageal Polypoid Carcinoma - Esophageal Pseudosarcomatous Squamous Cell Carcinoma - Esophageal Sarcomatoid Carcinoma - Esophageal Spindle Cell Carcinoma - Esophageal Squamous Cell Carcinoma with a Spindle-Cell Component