Gemcitabine Hydrochloride

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

**Synonyms:** - 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride - 2'Deoxy-2',2'-Difluorocytidine, Hydrochloride - Difluorodeoxycytidine Hydrochloride - GEMCITABINE HYDROCHLORIDE - Gemcitabine HCI - Gemzar - Gemzar - LY 188011 - LY-188011 - LY188011 - dFdCyd - gemcitabine hydrochloride