4'-Iodo-4'-Deoxydoxorubicin

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.

**Synonyms:** - 4'-Deoxy-4'-Iododoxorubicin - IDOX - IODODOXORUBICIN - Iodo-Doxorubicin - Iododoxorubicin - iododoxorubicin