Rho Guanine Nucleotide Exchange Factor 12

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Rho guanine nucleotide exchange factor 12 (1544 aa, ~173 kDa) is encoded by the human ARHGEF12 gene. This protein plays a role in the regulation of Rho-family GTPase- and G-protein coupled receptor-mediated signal transduction.

**Synonyms:** - ARHGEF12 - Leukemia-Associated RhoGEF