Ansamitomicin P-3

**Semantic type:** Pharmacologic Substance

**Definition:** An ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P-3 binds to tubulin at the maytansine-binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.

**Synonyms:** - ANSAMITOMICIN P-3 - Maytansine, 3-o-de(2-(acetylmethylamino)-1-oxopropyl)-3-o-(1-oxobutyl)-