Chloroquinoxaline Sulfonamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)

**Synonyms:** - Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)- - Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]- - CHLORSULFAQUINOXALINE - CQS - CQS - Chloroquinoxaline sulfonamide - Chlorsulfaquinoxaline - chloroquinoxaline sulfonamide - chlorosulfaquinoxaline