EML4/ALK Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal inversion inv(2)(p21p23) which fuses the 5' portion of the EML4 gene with exons 20-29 of the ALK gene. This fusion is associated with non-small cell lung cancer. Multiple transcript variants are possible based on the breakpoint for the EML4 gene.

**Synonyms:** - ALK/EML4 Fusion Gene - EML-4 ALK Translocation - EML-ALK Translocation - EML4-ALK Fusion Gene - EML4-ALK Gene Rearrangement - EML4-ALK Inversion - EML4-ALK Translocation - EML4/ALK Gene Mutation - EML4/ALK Gene Rearrangement - EML4/ALK Inversion - EML4/ALK Mutation - EML4/ALK Translocation - EML4::ALK Fusion Gene - Transforming Fusion Gene EML4-ALK