EML4/ALK Fusion Gene Variant 3a

**Semantic type:** Gene or Genome

**Definition:** A fusion gene (~2.5 kb) that results from a chromosomal inversion inv(2)(p21p23) which fuses exon 6a of the EML4 gene with exons 20-29 of the ALK gene. This fusion is associated with non-small cell lung cancer. Multiple transcript variants are possible based on the breakpoint for the EML4 gene.

**Synonyms:** - EML4-ALK Fusion Gene Variant 3a - EML4-ALK Variant 3 Splicing Isoform a Fusion Gene - EML4::ALK Fusion Gene Variant 3a - Transforming Fusion Gene EML4-ALK Variant 3a