Amonafide Dihydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.

**Synonyms:** - 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl) - AMONAFIDE DIHYDROCHLORIDE - Amonafide - Amonafide Hydrochloride - BIDA - Benzisoquinolinedione - M-FA-142 - Nafidimide - Quinamed - amonafide