Core Binding Factor alpha Subunits

**Definition:** A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

**Tree numbers:** - D12.776.930.155.200

**Synonyms:** - Polyomavirus Enhancer A Binding Protein 2 - Polyomavirus Enhancer Binding Protein 2, Alpha Subunit - Runt Domain Factor - Runx Proteins - Acute Myeloid Leukemia Proteins - PEBP2A Transcription Factors - Core Binding Factor alpha Proteins